Package 'egfr'

Title: Estimated Glomerular Filtration Rate (eGFR) Calculators
Description: A comprehensive, vectorised toolkit for estimating glomerular filtration rate (eGFR) and creatinine clearance from serum creatinine, cystatin C, or both. Implements 20 validated adult, paediatric, and neonatal equations, including CKD-EPI (2009, 2012, 2021), MDRD, Cockcroft-Gault, EKFC, FAS, Lund-Malmoe, the Berlin Initiative Study, Schwartz bedside, CKiD U25, CAPA, and a neonatal equation. Helpers for body surface area, CKD (KDIGO) staging, and unit conversions are included. Inspired by the 'kidney.epi' package.
Authors: Markus Hovd [aut, cre, cph]
Maintainer: Markus Hovd <[email protected]>
License: MIT + file LICENSE
Version: 1.1.0
Built: 2026-06-18 10:21:00 UTC
Source: https://github.com/mhovd/egfr

Help Index

Body surface area (BSA)

Description

Computes body surface area, used to convert between absolute (mL/min) and BSA-normalised (mL/min/1.73m^2) GFR.

Usage

bsa(weight, height, method = c("dubois", "haycock", "mosteller"))

Arguments

weight

Numeric vector of body weight in kilograms.
height

Numeric vector of height in centimetres.
method

One of "dubois" (Du Bois & Du Bois, default), "haycock", or "mosteller".

Value

Numeric vector of body surface area in m^2.

References

Du Bois D, Du Bois EF. Arch Intern Med. 1916;17:863-871. Haycock GB, et al. J Pediatr. 1978;93(1):62-66. Mosteller RD. N Engl J Med. 1987;317(17):1098.

Examples

bsa(weight = 80, height = 180)
bsa(weight = 20, height = 110, method = "haycock")

KDIGO CKD stage from eGFR

Description

Classifies eGFR values into KDIGO GFR categories (G1-G5).

Usage

ckd_stage(egfr)

Arguments

egfr

Numeric vector of eGFR in mL/min/1.73m^2.

Value

Character vector of GFR categories: "G1", "G2", "G3a", "G3b", "G4", or "G5".

References

Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 Clinical Practice Guideline. Kidney Int Suppl. 2013.

Examples

ckd_stage(c(95, 72, 50, 35, 20, 8))

Convert serum creatinine between mg/dL and umol/L

Description

Convert serum creatinine between mg/dL and umol/L

Usage

convert_creatinine(creatinine, from = "mg/dl", to = "umol/l")

Arguments

creatinine

Numeric vector of serum creatinine.
from, to

Units, either "mg/dl" or "umol/l".

Value

Numeric vector of converted creatinine.

Examples

convert_creatinine(88.4, from = "umol/l", to = "mg/dl")
convert_creatinine(1.0, from = "mg/dl", to = "umol/l")

Berlin Initiative Study (BIS1) creatinine eGFR (2012)

Description

Estimates GFR from serum creatinine using the BIS1 equation (Schaeffner et al., 2012), developed in an elderly (>= 70 years) German cohort.

Usage

egfr_bis_cr(
  creatinine,
  age,
  sex,
  creatinine_units = "mg/dl",
  label_sex_male = "male",
  label_sex_female = "female"
)

Arguments

creatinine

Numeric vector of serum creatinine.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Schaeffner ES, Ebert N, Delanaye P, et al. Two novel equations to estimate kidney function in persons aged 70 years or older. Ann Intern Med. 2012;157(7):471-481. doi:10.7326/0003-4819-157-7-201210020-00003

Examples

egfr_bis_cr(creatinine = 1.1, age = 75, sex = "female")

CAPA paediatric cystatin C eGFR (2014)

Description

Estimates GFR from serum cystatin C using the Caucasian, Asian, paediatric, and adult (CAPA) equation (Grubb et al., 2014).

Usage

egfr_capa(cystatin, age)

Arguments

cystatin

Numeric vector of serum cystatin C in mg/L.
age

Numeric vector of age in years.

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Grubb A, Horio M, Hansson LO, et al. Generation of a new cystatin C-based estimating equation for GFR by use of 7 assays standardized to the international calibrator. Clin Chem. 2014;60(7):974-986. doi:10.1373/clinchem.2013.220707

Examples

egfr_capa(cystatin = 1.0, age = 12)

CKD-EPI 2009 creatinine eGFR (with race coefficient)

Description

Estimates GFR from serum creatinine using the original CKD-EPI 2009 creatinine equation (Levey et al., 2009), which includes a race coefficient. Retained for historical comparison; the race-free egfr_ckdepi_cr_2021() is now recommended.

Usage

egfr_ckdepi_cr_2009(
  creatinine,
  age,
  sex,
  ethnicity = NULL,
  creatinine_units = "mg/dl",
  label_sex_male = "male",
  label_sex_female = "female",
  label_afroamerican = c("black", "Black")
)

Arguments

creatinine

Numeric vector of serum creatinine.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
ethnicity

Optional vector of ethnicity labels. Records matching label_afroamerican receive the Black race coefficient (1.159); all others receive 1.0. If NULL (default) no race coefficient is applied.
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".
label_afroamerican

Values in ethnicity denoting Black/African American race. Defaults to c("black", "Black").

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604-612. doi:10.7326/0003-4819-150-9-200905050-00006

Examples

egfr_ckdepi_cr_2009(creatinine = 1.0, age = 50, sex = "female")
egfr_ckdepi_cr_2009(1.0, 50, "female",
  ethnicity = "black", label_afroamerican = "black"
)

CKD-EPI 2021 creatinine eGFR (race-free)

Description

Estimates GFR from serum creatinine using the race-free CKD-EPI 2021 creatinine equation (Inker et al., 2021). This is the equation recommended for adults (>= 18 years) by current US guidelines.

Usage

egfr_ckdepi_cr_2021(
  creatinine,
  age,
  sex,
  creatinine_units = "mg/dl",
  label_sex_male = "male",
  label_sex_female = "female"
)

Arguments

creatinine

Numeric vector of serum creatinine.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Inker LA, Eneanya ND, Coresh J, et al. New creatinine- and cystatin C-based equations to estimate GFR without race. N Engl J Med. 2021;385(19):1737-1749. doi:10.1056/NEJMoa2102953

Examples

egfr_ckdepi_cr_2021(creatinine = 1.0, age = 50, sex = "female")
egfr_ckdepi_cr_2021(c(0.8, 1.2), c(40, 65), c("female", "male"))

CKD-EPI 2021 combined creatinine + cystatin C eGFR (race-free)

Description

Estimates GFR using both serum creatinine and cystatin C with the race-free CKD-EPI 2021 combined equation (Inker et al., 2021). This is the most accurate of the CKD-EPI equations when both biomarkers are available.

Usage

egfr_ckdepi_cr_cys_2021(
  creatinine,
  cystatin,
  age,
  sex,
  creatinine_units = "mg/dl",
  label_sex_male = "male",
  label_sex_female = "female"
)

Arguments

creatinine

Numeric vector of serum creatinine.
cystatin

Numeric vector of serum cystatin C in mg/L.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Inker LA, Eneanya ND, Coresh J, et al. N Engl J Med. 2021;385(19):1737-1749. doi:10.1056/NEJMoa2102953

Examples

egfr_ckdepi_cr_cys_2021(
  creatinine = 1.0, cystatin = 0.9,
  age = 50, sex = "female"
)

CKD-EPI 2012 cystatin C eGFR

Description

Estimates GFR from serum cystatin C using the CKD-EPI 2012 cystatin C equation (Inker et al., 2012). The formula is identical to the race-free 2021 cystatin C equation and is retained for backward compatibility.

Usage

egfr_ckdepi_cys_2012(
  cystatin,
  age,
  sex,
  label_sex_male = "male",
  label_sex_female = "female"
)

Arguments

cystatin

Numeric vector of serum cystatin C in mg/L.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Inker LA, Schmid CH, Tighiouart H, et al. Estimating GFR from serum creatinine and cystatin C. N Engl J Med. 2012;367(1):20-29. doi:10.1056/NEJMoa1114248

Examples

egfr_ckdepi_cys_2012(cystatin = 0.9, age = 55, sex = "male")

CKD-EPI 2021 cystatin C eGFR (race-free)

Description

Estimates GFR from serum cystatin C using the race-free CKD-EPI 2021 cystatin C equation (Inker et al., 2021). The identical formula was first published in 2012; see egfr_ckdepi_cys_2012().

Usage

egfr_ckdepi_cys_2021(
  cystatin,
  age,
  sex,
  label_sex_male = "male",
  label_sex_female = "female"
)

Arguments

cystatin

Numeric vector of serum cystatin C in mg/L.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Inker LA, Eneanya ND, Coresh J, et al. N Engl J Med. 2021;385(19):1737-1749. doi:10.1056/NEJMoa2102953

Examples

egfr_ckdepi_cys_2021(cystatin = 0.9, age = 55, sex = "male")

CKiD U25 creatinine eGFR

Description

Estimates GFR in children and young adults (ages 1-25) using the CKiD U25 creatinine equation (Pierce et al., 2021). This is the first-choice paediatric equation.

Usage

egfr_ckid_u25_cr(
  creatinine,
  age,
  sex,
  height,
  creatinine_units = "mg/dl",
  height_units = "cm",
  label_sex_male = "male",
  label_sex_female = "female"
)

Arguments

creatinine

Numeric vector of serum creatinine.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
height

Numeric vector of height.
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
height_units

Units of height: "cm" (default) or "m".
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Pierce CB, Munoz A, Ng DK, Warady BA, Furth SL, Schwartz GJ. Age- and sex-dependent clinical equations to estimate GFR in children and young adults with CKD. Kidney Int. 2021;99(4):948-956. doi:10.1016/j.kint.2020.10.047

Examples

egfr_ckid_u25_cr(creatinine = 0.6, age = 10, sex = "male", height = 140)

CKiD U25 combined creatinine + cystatin C eGFR

Description

Arithmetic mean of the CKiD U25 creatinine (egfr_ckid_u25_cr()) and cystatin C (egfr_ckid_u25_cys()) estimates.

Usage

egfr_ckid_u25_cr_cys(
  creatinine,
  cystatin,
  age,
  sex,
  height,
  creatinine_units = "mg/dl",
  height_units = "cm",
  label_sex_male = "male",
  label_sex_female = "female"
)

Arguments

creatinine

Numeric vector of serum creatinine.
cystatin

Numeric vector of serum cystatin C in mg/L.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
height

Numeric vector of height.
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
height_units

Units of height: "cm" (default) or "m".
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Pierce CB, et al. Kidney Int. 2021;99(4):948-956. doi:10.1016/j.kint.2020.10.047

Examples

egfr_ckid_u25_cr_cys(
  creatinine = 0.6, cystatin = 0.8, age = 10,
  sex = "male", height = 140
)

CKiD U25 extended creatinine eGFR (to age 30)

Description

Research extension of egfr_ckid_u25_cr() with kappa values that continue to age 30.

Usage

egfr_ckid_u25_cr_extended(
  creatinine,
  age,
  sex,
  height,
  creatinine_units = "mg/dl",
  height_units = "cm",
  label_sex_male = "male",
  label_sex_female = "female"
)

Arguments

creatinine

Numeric vector of serum creatinine.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
height

Numeric vector of height.
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
height_units

Units of height: "cm" (default) or "m".
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Pierce CB, et al. Kidney Int. 2021;99(4):948-956. doi:10.1016/j.kint.2020.10.047

Examples

egfr_ckid_u25_cr_extended(
  creatinine = 1.0, age = 28, sex = "female",
  height = 165
)

CKiD U25 cystatin C eGFR

Description

Estimates GFR in children and young adults (ages 1-25) using the CKiD U25 cystatin C equation (Pierce et al., 2021).

Usage

egfr_ckid_u25_cys(
  cystatin,
  age,
  sex,
  label_sex_male = "male",
  label_sex_female = "female"
)

Arguments

cystatin

Numeric vector of serum cystatin C in mg/L.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Pierce CB, et al. Kidney Int. 2021;99(4):948-956. doi:10.1016/j.kint.2020.10.047

Examples

egfr_ckid_u25_cys(cystatin = 0.8, age = 10, sex = "male")

Cockcroft-Gault creatinine clearance

Description

Estimates creatinine clearance (not BSA-normalised eGFR) using the Cockcroft-Gault equation (Cockcroft & Gault, 1976). Commonly used for drug dosing.

Usage

egfr_cockcroft_gault(
  creatinine,
  age,
  sex,
  weight,
  creatinine_units = "mg/dl",
  label_sex_male = "male",
  label_sex_female = "female"
)

Arguments

creatinine

Numeric vector of serum creatinine.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
weight

Numeric vector of body weight in kilograms.
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".

Value

Numeric vector of creatinine clearance in mL/min.

References

Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. doi:10.1159/000180580

Examples

egfr_cockcroft_gault(creatinine = 1.0, age = 50, sex = "male", weight = 80)

EKFC creatinine eGFR (2021)

Description

Estimates GFR from serum creatinine using the European Kidney Function Consortium (EKFC) creatinine equation (Pottel et al., 2021). Valid across the full age spectrum (2-120 years).

Usage

egfr_ekfc_cr(
  creatinine,
  age,
  sex,
  creatinine_units = "mg/dl",
  label_sex_male = "male",
  label_sex_female = "female",
  q = NULL
)

Arguments

creatinine

Numeric vector of serum creatinine.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".
q

Optional numeric vector of the reference creatinine Q value (median creatinine for the age/sex, in mg/dL). When NULL (the default) the built-in EKFC reference Q is used; supply a value to use a population-, assay-, or individual-specific Q. Recycled to the length of the other inputs.

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Pottel H, Bjork J, Courbebaisse M, et al. Development and validation of a modified full age spectrum creatinine-based equation to estimate glomerular filtration rate. Ann Intern Med. 2021;174(2):183-191. doi:10.7326/M20-4366

Examples

egfr_ekfc_cr(creatinine = 1.0, age = 50, sex = "female")
egfr_ekfc_cr(0.5, 8, "male")
egfr_ekfc_cr(1.0, 50, "female", q = 0.72)

EKFC combined creatinine + cystatin C eGFR (2023)

Description

Arithmetic mean of the EKFC creatinine (egfr_ekfc_cr()) and EKFC cystatin C (egfr_ekfc_cys()) estimates.

Usage

egfr_ekfc_cr_cys(
  creatinine,
  cystatin,
  age,
  sex,
  creatinine_units = "mg/dl",
  label_sex_male = "male",
  label_sex_female = "female",
  q_cr = NULL,
  q_cys = NULL
)

Arguments

creatinine

Numeric vector of serum creatinine.
cystatin

Numeric vector of serum cystatin C in mg/L.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".
q_cr

Optional numeric vector of the reference creatinine Q value (median creatinine, in mg/dL) passed to egfr_ekfc_cr(). NULL (default) uses the built-in EKFC reference Q.
q_cys

Optional numeric vector of the reference cystatin C Q value (median cystatin C, in mg/L) passed to egfr_ekfc_cys(). NULL (default) uses the built-in EKFC reference Q.

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Pottel H, Bjork J, Rule AD, et al. N Engl J Med. 2023;388(4):333-343. doi:10.1056/NEJMoa2203769

Examples

egfr_ekfc_cr_cys(creatinine = 1.0, cystatin = 0.9, age = 50, sex = "female")

EKFC cystatin C eGFR (2023)

Description

Estimates GFR from serum cystatin C using the sex- and race-free EKFC cystatin C equation (Pottel et al., 2023).

Usage

egfr_ekfc_cys(cystatin, age, q = NULL)

Arguments

cystatin

Numeric vector of serum cystatin C in mg/L.
age

Numeric vector of age in years.
q

Optional numeric vector of the reference cystatin C Q value (median cystatin C, in mg/L). When NULL (the default) the built-in age-based EKFC reference Q is used; supply a value to use a population- or individual-specific Q. Recycled to the length of the other inputs.

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Pottel H, Bjork J, Rule AD, et al. Cystatin C-based equation to estimate GFR without the inclusion of race and sex. N Engl J Med. 2023;388(4):333-343. doi:10.1056/NEJMoa2203769

Examples

egfr_ekfc_cys(cystatin = 0.9, age = 50)
egfr_ekfc_cys(0.9, 50, q = 0.85)

Full Age Spectrum (FAS) creatinine eGFR

Description

Estimates GFR from serum creatinine using the Full Age Spectrum equation (Pottel et al., 2016). Uses adult reference Q values (male 0.90, female 0.70 mg/dL) across all ages.

Usage

egfr_fas_cr(
  creatinine,
  age,
  sex,
  creatinine_units = "mg/dl",
  label_sex_male = "male",
  label_sex_female = "female"
)

Arguments

creatinine

Numeric vector of serum creatinine.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Pottel H, Hoste L, Dubourg L, et al. An estimated glomerular filtration rate equation for the full age spectrum. Nephrol Dial Transplant. 2016;31(5):798-806. doi:10.1093/ndt/gfv454

Examples

egfr_fas_cr(creatinine = 1.0, age = 50, sex = "female")

Lund-Malmoe Revised creatinine eGFR (2011)

Description

Estimates GFR from serum creatinine using the revised Lund-Malmoe equation (Bjork et al., 2011). Piecewise-linear in plasma creatinine (umol/L) with sex-specific knots.

Usage

egfr_lund_malmo(
  creatinine,
  age,
  sex,
  creatinine_units = "mg/dl",
  label_sex_male = "male",
  label_sex_female = "female"
)

Arguments

creatinine

Numeric vector of serum creatinine.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Bjork J, Grubb A, Sterner G, Nyman U. Revised equations for estimating glomerular filtration rate based on the Lund-Malmo Study cohort. Scand J Clin Lab Invest. 2011;71(3):232-239. doi:10.3109/00365513.2011.557086

Examples

egfr_lund_malmo(creatinine = 1.0, age = 50, sex = "female")

MDRD 4-variable eGFR (IDMS-standardised)

Description

Estimates GFR from serum creatinine using the IDMS-traceable 4-variable MDRD Study equation (Levey et al., 2006). Historical; superseded by CKD-EPI for clinical use.

Usage

egfr_mdrd(
  creatinine,
  age,
  sex,
  ethnicity = NULL,
  creatinine_units = "mg/dl",
  label_sex_male = "male",
  label_sex_female = "female",
  label_afroamerican = c("black", "Black")
)

Arguments

creatinine

Numeric vector of serum creatinine.
age

Numeric vector of age in years.
sex

Vector of sex labels (see label_sex_male/label_sex_female).
ethnicity

Optional vector of ethnicity labels. Records matching label_afroamerican receive the Black race coefficient (1.159); all others receive 1.0. If NULL (default) no race coefficient is applied.
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
label_sex_male, label_sex_female

Values in sex that denote male and female records. Defaults to "male"/"female".
label_afroamerican

Values in ethnicity denoting Black/African American race. Defaults to c("black", "Black").

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the MDRD study equation. Ann Intern Med. 2006;145(4):247-254. doi:10.7326/0003-4819-145-4-200608150-00004

Examples

egfr_mdrd(creatinine = 1.2, age = 60, sex = "male")

Neonatal creatinine eGFR (2022)

Description

Estimates GFR in term-born neonates using the equation of Smeets et al. (2022). Requires IDMS-standardised creatinine.

Usage

egfr_neonatal(
  creatinine,
  height,
  creatinine_units = "mg/dl",
  height_units = "cm"
)

Arguments

creatinine

Numeric vector of serum creatinine.
height

Numeric vector of height.
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
height_units

Units of height: "cm" (default) or "m".

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Smeets NJL, IntHout J, van der Burgh MJP, et al. SCr- and cystatin C-based equations to estimate GFR in term-born neonates. J Am Soc Nephrol. 2022;33(7):1277-1292. doi:10.1681/ASN.2021111453

Examples

egfr_neonatal(creatinine = 0.5, height = 50)

Schwartz bedside paediatric eGFR (2009)

Description

Estimates GFR in children using the bedside Schwartz equation (Schwartz et al., 2009). Requires IDMS-standardised creatinine.

Usage

egfr_schwartz(
  creatinine,
  height,
  creatinine_units = "mg/dl",
  height_units = "cm"
)

Arguments

creatinine

Numeric vector of serum creatinine.
height

Numeric vector of height.
creatinine_units

Units of creatinine: "mg/dl" (default) or "umol/l".
height_units

Units of height: "cm" (default) or "m".

Value

Numeric vector of eGFR in mL/min/1.73m^2.

References

Schwartz GJ, Munoz A, Schneider MF, et al. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009;20(3):629-637. doi:10.1681/ASN.2008030287

Examples

egfr_schwartz(creatinine = 0.5, height = 120)

Normalise or de-normalise GFR using body surface area

Description

Converts between absolute creatinine clearance (mL/min) and BSA-normalised GFR (mL/min/1.73m^2).

Usage

gfr_bsa_adjust(gfr, bsa, to = c("normalized", "absolute"))

Arguments

gfr

Numeric vector of GFR values.
bsa

Numeric vector of body surface area in m^2 (e.g. from bsa()).
to

Either "normalized" (absolute -> per 1.73m^2, the default) or "absolute" (per 1.73m^2 -> absolute).

Value

Numeric vector of converted GFR.

Examples

gfr_bsa_adjust(100, bsa = 2.0, to = "normalized")
gfr_bsa_adjust(90, bsa = 2.0, to = "absolute")